Computer systems and methods for genotype to phenotype mapping using molecular network models

摘要

A computer system and methods are provided for mapping genotypes to phenotypes. The system includes a molecular network model and an optimizer. Functions of the molecular network model called trait functions are implemented to compute simulated phenotypes of the network. Simulated phenotypes are numerical properties of the molecular network that correspond to observed phenotypes which are observable properties of the biological system represented by the molecular network model. The optimizer optimizes the network to fit simulated phenotypes to observed phenotypes. The genotype to phenotype mapping system is useful in prediction of phenotypes, identification of phenotypic differences among polymorphic genotypes, determination of environmental effects on phenotypic development, determination of differences in patient response to a therapeutic agent due to genetic polymorphism, and genetic engineering of a target phenotype. Also provided are computer program products implementing the disclosed computer systems, computer data structures representing genotypic and phenotypic data, and computer readable media capable of storing such data structures.