发明名称 |
Genomically modified cell neutralized to serum-free system |
摘要 |
<p>Development of a host cell capable of producing a glycoprotein composition such as an antibody composition which is useful in development of medicaments is desired. The present invention provides a cell in which a genomic gene encoding an enzyme relating to a sugar chain modification in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ±-bond in a complex type N-glycoside-linked sugar chain is knocked out, wherein the cell is naturalized in a serum-free medium and a process for producing a glycoprotein composition using the cell.</p> |
申请公布号 |
AU2004280064(A1) |
申请公布日期 |
2005.04.21 |
申请号 |
AU20040280064 |
申请日期 |
2004.10.08 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
MITSUO SATOH;SATOKO KINOSHITA;MIHO INOUE;RYOSUKE NAKANO;SHIGERU IIDA;MACHI KUSUNOKI;NAOKO OHNUKI |
分类号 |
C12N15/13;C12N5/00;C12N5/10;C12P21/08 |
主分类号 |
C12N15/13 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|