发明名称 |
ПРИМЕНЕНИЕ СОЕДИНЕНИЙ РЕДКОЗЕМЕЛЬНЫХ МЕТАЛЛОВ ДЛЯ ПРЕДОТВРАЩЕНИЯ МОЧЕКАМЕННОЙ БОЛЕЗНИ |
摘要 |
A pharmaceutical composition comprises a salt of a rare earth metal (S1) and at least one nontoxic counterion (C1). (S1) Is optionally hydrated. ACTIVITY : Nephrotropic; Uropathic. MECHANISM OF ACTION : Oxalate Absorption Inhibitor. Stock sodium oxalate solution (50 ml) containing sodium chloride (8.5 g/l) was adjusted to either pH 3 or pH 7. Prior to the addition of lanthanum carbonate, a 2 ml sample was taken as a zero time point sample. The volume of buffer was made up to 50 ml, pH was adjusted and lanthanum carbonate was added so that a concentration of 0.1 M was present in the 50 ml of either pH 3 or pH 7 phosphate/oxalate buffer. A timer was started and 2 ml samples were removed at pre-determined time intervals over twenty minutes and analyzed. A phosphorus assay was performed as given in Sigma procedure 670. The results indicated that even in the presence of 10-fold excess phosphate, lanthanum carbonate bind oxalate. |
申请公布号 |
RU2003133991(A) |
申请公布日期 |
2005.04.20 |
申请号 |
RU20030133991 |
申请日期 |
2002.04.22 |
申请人 |
АНОРМЕД ИНК. (CA) |
发明人 |
ЭБРАМС Майкл Дж (US);БРИДЖЕР Гари Дж (US);ФРИКЕР Саймон П. (CA);ИДЗАН Стефан Р. (CA) |
分类号 |
A61K33/24;A61K31/28;A61K33/00;A61P13/12 |
主分类号 |
A61K33/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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