| 发明名称 |
Disulfide conjugated cell toxins and methods of making and using them |
| 摘要 |
The invention pertains to the discovery of novel disulfide linked cell toxins which can ablate NK-1 receptor expressing cells. These toxins are used as pharmaceutical compositions for the ablation of NK1 receptor expressing cells and comprise a substance P (SP)-Pseudomonas exotoxin disulfide linked conjugate. The invention also includes methods of making and using these toxins and pharmaceutical compositions.
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| 申请公布号 |
US6881718(B1) |
申请公布日期 |
2005.04.19 |
| 申请号 |
US20020110934 |
申请日期 |
2002.04.17 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
FITZGERALD DAVID J.;IADAROLA MICHAEL J. |
| 分类号 |
A61K38/00;A61K47/48;C07K7/22;C07K14/21;C12N15/31;(IPC1-7):C07K1/36;C07K2/00 |
主分类号 |
A61K38/00 |
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