VACCINES AGAINST AUJESZKY'S DISEASE AND OTHER ANIMAL DISEASES CONTAINING PSEUDORABIES VIRUS MUTANTS

摘要

The invention provides vaccines for preventing and controlling animal diseases, comprising a pseudorabies virus containing glycoprotein gp50 and having a mutation in its gp50 gene. The vaccines are suitable for use against Aujeszky's disease (pseudorabies), or against other animal diseases when the mutation is an insertion comprisin g a heterologous gene encoding an antigen corresponding to said animal disease. The pseudorabies virus may additionall y have at least one mutation in one of its other genes, such as the gp63 gene or the g1 gene. The vaccines are unable to spre ad from vaccinated to non-vaccinated animals.