发明名称 |
PROCEDIMIENTO PARA DETECTAR INHIBIDORES DE LA SINTESIS DE NUCLEOTIDOS CON MENOS EFECTOS SECUNDARIOS. |
摘要 |
The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a mammal. The concentration of the nucleotide synthesis inhibitor in the blood of the mammal is observed and it is determined whether the nucleotide synthesis inhibitor has a half-life which is shorter than that of N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide. The invention also relates to a method of using nucleotide synthesis inhibitors in the treatment of immunological diseases.
|
申请公布号 |
ES2228665(T3) |
申请公布日期 |
2005.04.16 |
申请号 |
ES20000993378T |
申请日期 |
2000.11.30 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
LINDNER, JURGEN;HAASE, BURKHARD |
分类号 |
G01N33/48;A61K31/275;A61P37/00;G01N33/15;G01N33/50;(IPC1-7):A61K31/275 |
主分类号 |
G01N33/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|