发明名称 |
SHIGA-TOXIN-UNTEREINHEIT B ALS VEKTOR ZUR DIAGNOSE VON TUMOREN UND ZUR ARZNEIMITTELVERABREICHUNG AN GB3-EXPRIMIERENDEN TUMOREN |
摘要 |
The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds having the following formula: STxB-Z(n)-Cys-Y(m)- T wherein STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, T is a molecule linked by a covalent bound to the S part of Cys, Y is a linker between T and Cys. |
申请公布号 |
AT292144(T) |
申请公布日期 |
2005.04.15 |
申请号 |
AT20020291962T |
申请日期 |
2002.08.02 |
申请人 |
INSTITUT CURIE;UNIVERSITE PIERRE ET MARIE CURIE PARIS VI;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
JOHANNES, LUDGER;FLORENT, JEAN-CLAUDE;GRIERSON, DAVID;MAILLARD, PHILIPPE;ROBINE, SYLVIE;ROGER, JACKY |
分类号 |
A61K38/00;A61K41/00;A61K47/48;A61K49/00;A61K49/14;C07K14/25;C07K14/36;G01N33/574;(IPC1-7):C07K14/25 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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