| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for more accurately determining the sensitizing potential intensity of a test chemical substance in a short time. SOLUTION: The method for rating the sensitizing potential intensity of a test chemical substance comprises the step(1) of preparing a standard solution(A) made by dissolving a standard chemical substance with known sensitizing potential intensity to a specified concentration and a test solution(B) made by dissolving a test chemical substance to the same concentration as that for the standard solution(A), the step(2) of applying the solution(A) to a group of control test animals and the solution(B) to a group of test animals, the step(3) of sampling the auricular lymph nodes of each of the test animals and assaying an indicator representing the cell proliferation extent of each of the auricular lymph nodes, and the step(4) of making a relative comparison of an indicator representing the cell proliferation extent of the auricular lymph nodes for the control test animal group and that for the test animals. COPYRIGHT: (C)2005,JPO&NCIPI
|
