The present invention provides optimized transfection reagents comprising mixtures of cationiclipoids. In particular, the present invention provides DNA delivery vehicles based on identifying the optimal hydrophobicity of novel cationic phospholipid derivatives that, alone or in combination, form complexes with DNA (lipoplexes) and exhibit enhanced transfection activity.
申请公布号
WO2005033289(A2)
申请公布日期
2005.04.14
申请号
WO2004US32519
申请日期
2004.10.04
申请人
NORTHWESTERN UNIVERSITY;MACDONALD, ROBERT, C.;WANG, LI