ANGIOTENSIN-CONVERTING ENZYME-2 AS A RECEPTOR FOR THE SARS CORONAVIRUS
摘要
The present invention is based upon the identification of human angiotensinconverting enzyme-2 (ACE-2) as a functional receptor for the SARS coronavirus. Transfection of cells with ACE-2 confers upon them the ability to support viral replication. In addition, assays performed using ACE-2 together with the S protein of the SARS virus or a fragment derived from the S protein can be used to identify inhibitors that block the interaction between virus and host cell.
申请公布号
WO2005032487(A2)
申请公布日期
2005.04.14
申请号
WO2004US32877
申请日期
2004.10.05
申请人
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;FARZAN, MICHAEL;LI, WENHUI;MOORE, MICHAEL, J.