SALTS AND POLYMORPHS OF A PYRROLE-SUBSTITUTED INDOLINONE COMPOUND

摘要

The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1 ,2-dihydro-3H-­indol-3-ylidene)methyl]-N-[(2 )-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3­-carboxamide,shown in structural formula 1 such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1 ,.2-dihydro-3H-indol-3­- ylidene)methyl]-N-[(2S)-2-hyd carboxamide salts, and meth roxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3­ ds of treating disorders such as cancer using such compositions.