发明名称 |
Methods of inhibiting osteoclast activity |
摘要 |
Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Pharmaceutical compositions which comprise TRANCE/RANK inhibitor in an amount effective to inhibit osteoclastogenesis. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of a TRANCE/RANK inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
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申请公布号 |
US2005080133(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20030625073 |
申请日期 |
2003.07.22 |
申请人 |
GREENE MARK I.;MURALI RAMACHANDRAN;KINOSAKI MASAHIKO |
发明人 |
GREENE MARK I.;MURALI RAMACHANDRAN;KINOSAKI MASAHIKO |
分类号 |
A61K31/00;A61K31/03;A61K31/235;A61K31/565;A61K31/585;A61K38/00;A61K38/17;C07K5/103;C07K5/107;C07K5/113;C07K14/705;(IPC1-7):A61K31/235 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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