Disclosed are compositions and methods for modulating endothelial cells (ECs) in a mammal. Practice of the invention generally involves changing activity of the ezrin cytoskeletal protein sufficient to increase or decrease proliferation of the cells. Also disclosed are useful screens for detecting agents capable of modulating ezrin activity. The invention has a variety of useful applications including use in the treatment of diseases associated with unsatisfactory EC proliferation.
申请公布号
WO2004016739(A3)
申请公布日期
2005.04.14
申请号
WO2003US23978
申请日期
2003.08.01
申请人
CARITAS ST. ELIZABETH'S MEDICAL CENTER OF BOSTON,;LOSORDO, DOUGLAS, W.;KISHORE, RAJ