CHEMICAL TREATMENT FOR REMOVING CELLULAR AND NUCLEAR MATERIAL FROM NATURALLY OCCURRING EXTRACELLULAR MATRIX-BASED BIOMATERIALS

摘要

A method is provided for sequential decellurization of an isolated tissue using solubilizing solutions comprising at least one oxidizing agent that removes all cellular and nuclear materials from the tissue while substantially maintaining the biological and, mechanical properties, and the biochemical properties of the resulting extracellular matrix.