发明名称 |
Method for redesign of microbial production systems |
摘要 |
A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stiochiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.
|
申请公布号 |
US2005079482(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20040929091 |
申请日期 |
2004.08.26 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
MARANAS COSTAS D.;BURGARD ANTHONY P.;PHARKYA PRITI |
分类号 |
G01N33/50;G06F19/00;(IPC1-7):C12Q1/00;G01N33/48 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|