| 摘要 |
This invention describes the new 17alpha-fluoroalkyl steroids of general formula I in which R<1 >stands for a methyl or ethyl group, R<2 >stands for a radical of formula CnFmHo, whereby n is 2, 3, 4, 5 or 6, m>1 and m+o=2n+1, R<3 >stands for a free, etherified or esterified hydroxy group, R<4 >and R<5 >each stand for a hydrogen atom, or together for an additional bond or a methylene group, St stands for a steroidal ABC-ring system of partial formula A, B or C in which R<6 >means a hydrogen atom, a straight-chain C1-C4 alkyl group or branched C3-C4 alkyl group or a halogen atom, R<7 >means a hydrogen atom, a straight-chain C1-C4 alkyl group or a branched C3-C4 alkyl group, or if St stands for a steroidal ABC-ring system A or B, in addition R<6 >and R<7 >together can mean an additional bond, X means an oxygen atom, a hydroxyimino grouping =N-OH or two hydrogen atoms, R<8 >means a radical Y or an aryl radical that is optionally substituted in several places with a group Y, whereby Y is a hydrogen atom, a halogen atom, an -OH, -NO2, -N3, -CN, -NR<9a>R<9b>, -NHSO2R<9>, -CO2R<9>, C1-C10 alkoxy, C1-C10 alkanoyloxy, benzoyloxy, C1-C10 alkanoyl, C1-C10 hydroxyalkyl or benzoyl group, and R<9a >and R<9b >are the same or different and in the same way as R<9 >represent a hydrogen atom or a C1-C10 alkyl group, and for -NR<9a>R<9b >radicals, as well as their physiologically compatible salts with acids and for -CO2R<9 >radicals with R<9 >meaning hydrogen, as well as their physiologically compatible salts with bases. The new compounds have an extraordinarily strong antigestagenic action and are suitable for the production of pharmaceutical preparations.
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