METHOD FOR DETERMINING AN ACTIVE INGREDIENT DOSAGE

摘要

The invention relates to a method for determining the dosage of at least one active ingredient based on a genetic analysis. The method comprises the following steps: a) analysis (101) of specific genetic sequences, using a genetic sequence-specific analysis device, in particular a sequence-specific sensor, or determination of the expression of proteins, either by RNA transcription using quantitative RNA-specific identification methods or by the direct measurement of the protein expression by a protein analysis device; b) assignment of the genetic sequences to physiological functions of the human or animal body, in particular to those physiological functions that influence the decomposition, absorption, release or distribution behaviour of the active ingredient in the body; c) transmission of the genetic and assignment data to a physiology-based pharmacokinetic model (PBPK model) (108); d) input of active ingredient-specific data into the PBPK model (108); e) input of characteristic patient data, optionally from direct measurements on the body; f) calculation of physiological influence parameters that are required for the PBPK model from the patient data, using information contained in the knowledge database and transmission of said parameters to the PBPK model (108); g) calculation of the individual dose from the data in steps c), d) and f), using the PBPK model (108).