发明名称 |
COMPOSITIONS AND METHODS FOR SELECTIVE INHIBITION OF NICOTINE ACETYLCHOLINE RECEPTORS |
摘要 |
The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a pharmaceutically acceptable salt thereof, to the patient. In another aspect, the present invention pertains to pharmaceutical compositions containing TMPH, or a phannaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to methods for selectively inhibiting nicotinic acetylcholine receptors that lack an a5, a6, or beta3 subunit by contacting an effective amount of TMPH, or a pharmaceutically acceptable salt thereof, to the receptor. The method for selectively inhibiting nicotinic acethylcholine receptors that lack an a5 subunit can be carried out in vivo or in vitro. |
申请公布号 |
WO2005032479(A2) |
申请公布日期 |
2005.04.14 |
申请号 |
WO2004US32363 |
申请日期 |
2004.09.30 |
申请人 |
UNVIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;PAPKE, ROGER, L.;HORENSTEIN, NICOLE, A.;FRANCIS, MICHAEL, M.;CHOI, KYUNG, IL |
发明人 |
PAPKE, ROGER, L.;HORENSTEIN, NICOLE, A.;FRANCIS, MICHAEL, M.;CHOI, KYUNG, IL |
分类号 |
A61K;A61K31/445;C07D211/36;C07D211/44 |
主分类号 |
A61K |
代理机构 |
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地址 |
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