| 摘要 |
The present invention relates generally to modulation of immune responses by administration of compositions comprising macrolide antibiotics, such as roxithromycin, and use of those compositions in methods for treating or preventing diseases or disorders involving transendothelial migration of T cells and activated T cells, proinflammatory cytokine production from T cells, and IL-6 production from macrophages. The present invention further relates to the use of such macrolide antibiotic compositions to treat or prevent arthritic and rheumatic disorders, such as rheumatoid arthritis, and to inhibit the development or progression of or one or more of the symptoms of such as a disorder, including joint swelling and tenderness, synovial membrane proliferation, pannus formation, and bone and cartilage destruction. |
