METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE PROTEIN ACTIVITY
摘要
Methods of identifying compounds that modulate target polypeptide activity, where a test compound is combined with a target polypeptide and a substrate of the target polypeptide and where a determination is made as to whether the test compound modulates activity of the target polypeptide. The test compounds could be small molecule drugs used for treatment of obestiy, diabetes, insulin resistance, and for enhancement of insulin secretion. Target polypeptides and their corresponding nucleic acids as well as their variants are also disclosed.
申请公布号
WO2004013347(A3)
申请公布日期
2005.04.14
申请号
WO2003US24504
申请日期
2003.08.06
申请人
CURAGEN CORPORATION
发明人
BERGHS, CONSTANCE;ELLERMAN, KAREN;GUO, XIAOJIA;LI, LI;ORT, TATIANA;RIEGER, DANIEL, K.;VERNET, CORINE, A., M.;ZHONG, MEI