发明名称 |
Combination bacteriolytic therapy for the treatment of tumors |
摘要 |
Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascutar compartments of transplanted tumors. Among 26 different strains tested, one (Clostridium novyi) appeared particularly promising. We created a strain of C. novyi devoid of its lethal toxin (C. novyi-NT) and showed that intravenously injected C. novyi-NT spores germinated within the avascular regions of tumors in mice and destroyed surrounding viable tumor cells. When C. novyi-NT spores were administered together with conventional chemotherapeutic drugs, extensive hemorrhagic necrosis of tumors often developed within 24 hours, resulting in significant and prolonged anti-tumor effects. This strategy, called combination bacteriolytic therapy (COBALT), has the potential to add a valuablle dimension to the treatment of cancer. |
申请公布号 |
US2005079157(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20040495116 |
申请日期 |
2004.11.23 |
申请人 |
DANG LONG;KINZLER KENNETH;VOGELSTEIN BERT |
发明人 |
DANG LONG;KINZLER KENNETH;VOGELSTEIN BERT |
分类号 |
A61K31/475;A61K35/74;A61K41/00;A61K45/06;C12N1/21;(IPC1-7):A61K48/00 |
主分类号 |
A61K31/475 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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