发明名称 |
Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds |
摘要 |
Reduced-immunogenic fusion compounds are disclosed. The fusion compounds of the invention comprise immunogenic compounds linked to auto-antigenic sequences which render the compound less immunogenic. In addition, a method of reducing the immunogenicity of an immunogenic compound is disclosed. The method comprises linking an auto-antigenic sequence to an otherwise immunogenic compound. Recombinant nucleotide sequence encoding auto-antigenic sequences are also disclosed.
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申请公布号 |
US2005079183(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20030653706 |
申请日期 |
2003.09.02 |
申请人 |
CENTOCOR, INC. |
发明人 |
JORDAN ROBERT E.;WAGNER CARRIE LYNNE;KNIGHT DAVID M. |
分类号 |
A61K38/00;C07K14/315;C07K14/47;C07K16/00;C07K16/46;C12P21/08;(IPC1-7):A61K39/395;C07K16/44 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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