METHOD OF EXTENDING SINGLE-STRANDED NUCLEIC ACID, SINGLE-STRANDED NUCLEIC ACID EXTENDING APPARATUS AND DNA CHIP

摘要

The action of high-frequency AC electric field on a single-stranded nucleic acid being present in an aqueous solution is verified, and the action is utilized for enhancement of the efficiency of hybridization for conversion of the single-stranded nucleic acid to a companion complementary strand. There are provided, for example, a method of nucleic acid extension and nucleic acid extending apparatus, wherein high-frequency AC electric field is applied to a single-stranded nucleic acid being present in liberated form in pure water or an aqueous solution of 5 to 11 pH (R), or to a single-stranded nucleic acid fixed onto the surface (f) of one or both (E) of counter electrodes (E,E) provided so as to face the aqueous solution (R), thereby extending the single-stranded nucleic acid.