发明名称 |
Treating stress response with chemokine receptor ccr5 modulators |
摘要 |
The use of chemokine receptor CCR5 modulators (e.g., CCR5 antagonists) is disclosed for the treatment or prevention of stress response (e.g., fever) in a subject resulting from surgery, infection or other insult to the subject (e.g., a warm-blooded vertebrate). Methods for treating or preventing disorders involving the activation of pro-inflammatory cytokines by administration of a CCR5 modulator, for inhibiting the endogenous production of pro-inflammatory cytokines by the administration of CCR5 modulators, and for determining the efficacy of CCR5 modulators in correcting abnormal levels of pro-inflammatory cytokines are also disclosed.
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申请公布号 |
US2005079176(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20040501999 |
申请日期 |
2004.07.20 |
申请人 |
PIERSON III RICHARD N.;AZIMZADEH AGNES M.;SCHROEDER CARSTEN;DEMARTINO JULIE A. |
发明人 |
PIERSON III RICHARD N.;AZIMZADEH AGNES M.;SCHROEDER CARSTEN;DEMARTINO JULIE A. |
分类号 |
C07D413/04;A61K31/445;A61K31/454;A61K38/00;A61K39/395;A61K45/00;A61P7/00;A61P7/08;A61P9/00;A61P9/02;A61P11/00;A61P17/02;A61P19/00;A61P25/04;A61P29/00;A61P31/04;A61P37/02;A61P37/06;A61P39/00;A61P41/00;A61P43/00;C07D401/04;C07D415/00;C07D471/04;C07D513/04;(IPC1-7):A61K39/395;A61K31/00 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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地址 |
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