发明名称 |
NOVEL ANTISENSE OLIGOMERS AND USE THEREOF |
摘要 |
The invention relates to the use of a novel type of antisense oligomers for use in the in vitro or in vivo inhibition of gene expression of a target gene. These oligomers, called exon-bridging oligomers are complementary to those parts of a spliced mRNA which are derived from two adjacent exons in the primary RNA transcript, and are called exon-bridging antisense oligomers. These oligomers have no complimentarity to genomic DNA. These oligomers can be used to performs antisense inhibition with less aspecific binding to genomic DNA. The exon-bridging oligomers are suitable for inhibiting Interleukin1 type I Receptor in, for instance, chondrocytes, and are suitable for the prevention or treatment of osteoarthritis. |
申请公布号 |
WO2005033694(A2) |
申请公布日期 |
2005.04.14 |
申请号 |
WO2004BE00142 |
申请日期 |
2004.10.06 |
申请人 |
UNIVERSITEIT GENT;VERBRUGGEN, AUGUST;ELEWAUT, DIRK;WAN, JUN |
发明人 |
VERBRUGGEN, AUGUST;ELEWAUT, DIRK;WAN, JUN |
分类号 |
A61K38/00;C07H21/00;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
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