发明名称 |
MODULATORS OF PARAPTOSIS AND RELATED METHODS |
摘要 |
The invention is directed to a method of identifying a compound that modulates SP-induced paraptosis by (a) contacting a population of cells with an effective amount of substance P to induce SP-induced paraptosis; (b) contacting a first sub-population of the cells with a test-compound, and a second sub-population of the cells with a control-compound; and (c) comparing the amount of cell death between the first and second sub-populations of cells, where a difference in he amount of cell death between the first and second sub-populations of cells indicates that the test-compound is a compound that modulates SP-induced paraptosis. The invention is also directed to a method of modulating paraptotic cell death in a cell by contacting the cell with an effective amount of a compound selected from the group consisting of ceramide, Tumor Necrosis Factor (TNF), caspase-7, caspase-8, alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA), kainic acid and glutamic acid, wherein the effective amount of the compound induces paraptotic death of the cell. |
申请公布号 |
WO03070971(A3) |
申请公布日期 |
2005.04.14 |
申请号 |
WO2003US05221 |
申请日期 |
2003.02.19 |
申请人 |
BUCK INSTITUTE;SPERANDIO, SABINA;CASTRO-OBREGON, SUSANA;BREDESEN, DALE, E. |
发明人 |
SPERANDIO, SABINA;CASTRO-OBREGON, SUSANA;BREDESEN, DALE, E. |
分类号 |
A61K31/00;A61K31/198;A61K31/40;A61K31/421;A61K31/739;A61K38/04;A61K38/17;A61K38/19;A61K38/48;A61K45/06;G01N33/50 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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