发明名称 |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells |
摘要 |
The bispecific antibodies of the present invention are in the form of a heteroconjugate that inhibits growth and induces apoptosis of a diseased cell and that does not require the recruitment of effector cells. The heteroconjugate has at least two binding arms wherein each of the binding arms possesses a different specificity and need not have apoptotic activity when not conjugated to each other. Also provided are methods of treating and diagnosing a diseased cell using the bispecfic antibodies of the present invention.
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申请公布号 |
US2005079184(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
US20040913509 |
申请日期 |
2004.08.09 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
HSING-CHANG CHIEN;GOLDENBERG DAVID M.;HANSEN HANS J.;HORAK EVA;HORAK IVAN D. |
分类号 |
A61K39/395;C07K;C07K16/28;C07K16/30;C07K16/46;G01N33/574;(IPC1-7):G01N33/574 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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