发明名称 |
MAMMALIAN CELL LINES MODIFIED FOR THE PRODUCTION OF RECOMBINANT GLYCOPROTEINS |
摘要 |
Novel, genetically modified mammalian cell lines are described, which can produce glycoconjugates the oligosaccharide portions of which are more similar to the human one than those of the same glycoconjugates produced by cells which have not been genetically modified. The lines in question can be used for the production of recombinant glycoconjugates which are of therapeutic interest, in particular for the production of glycoproteins for use in human therapy, since the glycoconjugates produced in these modified lines have a lower immunogenic potential for man than corresponding glycoconjugates produced in cells which have not been genetically modified. |
申请公布号 |
WO2005033303(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
WO2004IT00529 |
申请日期 |
2004.09.27 |
申请人 |
KERYOS S.P.A.;TONON, GIANCARLO;POZZUOLO, SABRINA;MONACO, LUCIA |
发明人 |
TONON, GIANCARLO;POZZUOLO, SABRINA;MONACO, LUCIA |
分类号 |
C12N9/02;C12P21/00 |
主分类号 |
C12N9/02 |
代理机构 |
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代理人 |
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