发明名称 |
USE OF CRIPTO-1 AS A BIOMARKER FOR NEURODEGENERATIVE DISEASEAND METHOD OF INHIBITING PROGRESSION THEREOF |
摘要 |
<p>A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the Cripto-1 gene product is indicative of a neurodegenerative disease in the mammal; a method of inhibiting progression of a neurodegenerative disease in a mammal, which method comprises administering to the mammal an agent that inhibits Cripto-1 in an amount effective to inhibit Cripto-1 in the central nervous system of the mammal, whereupon the progression of the neurodegenerative disease is inhibited; and an isolated or purified oligonucleotide consisting essentially of the sequence of AAGCTATGGACTGCAGGAAGATGG (SEQ ID NO: 3) or AGAAGGCAGATGCCACTAGC (SEQ ID NO: 4).</p> |
申请公布号 |
CA2539535(A1) |
申请公布日期 |
2005.04.14 |
申请号 |
CA20042539535 |
申请日期 |
2004.10.01 |
申请人 |
UNIVERSITY OF KANSAS MEDICAL CENTER;GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY , D |
发明人 |
STEPHENS, EDWARD;SALOMON, DAVID;BERMAN, NANCY |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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