发明名称 |
TRANSGENIC ANIMAL EXPRESSING TRUNCATED ALZHEIMER'S TAU PROTEIN |
摘要 |
Described are novel N- and C-terminally double truncated tau molecules, herein after designated type IIB tau molecules, characterized by the following features:
- the molecules have at least the first 68 N-terminal amino acids and at least the last 40 C-terminal amino acids of the 4 repeat containing tau43 or the first 68 N-terminal amino acids and at least the last 20 C-terminal amino acids of the 3 repeat containing tau44 truncated,
- the molecules are detectable in Alzheimer's diseased brain tissue, whereas the molecules are not detectable in normal healthy brain tissue,
- the molecules have a pathological microtubule assembly promoting activity different from wild type tau in an in vitro microtubule assembly assay. |
申请公布号 |
EP1521831(A2) |
申请公布日期 |
2005.04.13 |
申请号 |
EP20030763764 |
申请日期 |
2003.07.09 |
申请人 |
AXON NEUROSCIENCE FORSCHUNGS- UND ENTWICKLUNGS GMBH |
发明人 |
KONTSEKOVA, EVA;FILIPCIK, PETER |
分类号 |
A01K67/027;A61K39/00;C07K14/47;C12N5/10;C12N15/09;C12N15/12;C12N15/85;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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