| 摘要 |
The present invention provides compounds which can modulate receptor kinase activity, particularly ephrin and EGFR, pharmaceutical compositions thereof and such compounds for use in treating cancer. The compounds comprise N-(3,4-dichloro-2-fluorophenyl)-7-({[(3aR,5r,6aS)-2-methyloctahydrocyclopenta [c]pyrrol-5-yl]methyl}oxy)-6-(methyloxy)quinazolin-4-amine and N-(3,4-dichloro-2-fluorophenyl)-7-({[(3aR,5s,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methyl}oxy)-6-(methyloxy)quinazolin-4-amine. |
| 申请人 |
EXELIXIS, INC. |
发明人 |
RICE, KENNETH, D.;ANAND, NEEL, KUMAR;BUSSENIUS, JOERG;COSTANZO, SIMONA;KENNEDY, ABIGAIL, R.;KIM, ANGIE, I.;PETO, CSABA, J.;TSANG, TSZE, H.;BLAZEY, CHARLES, M. |
