Beads with immobilized amphiphilic molecules, method of fabrication thereof, and method of arraying beads for capillary beads-array

摘要

A capillary beads-array attractive to users is provided by immobilizing amphiphilic molecules on the surface of beads (212) in uniform orientation and arraying the beads in a capillary formed on a soft resin. A monomolecular layer of the amphiphilic molecules is formed on the bead surface (212) by putting beads having hydrophilic portions on the surface in water phase, dropping amphiphilic molecules containing a hydrophilic portion and a hydrophobic portion onto the water phase, pouring an oil lighter than water to form a monomolecular film of the amphiphilic molecules at an oil/water interface (205), capturing a single bead with the tip of a bead picker (211), lifting up the tip of the bead picker (211) to allow the bead (212) to reach the oil/water interface (205), and allowing to form a covalent bond between a functional group in the hydrophilic portion on the bead surface (212) and a functional group in the hydrophilic portion of the amphiphilic molecules. <IMAGE>