Anti-inflammatory androstane derivatives

摘要

According to one aspect of the invention, there is provided a pharmaceutical formulation for administration by inhalation comprising a compound of formula (I),whereinR1 represents C1-6 alkyl or C1-6 haloalkyl;R2 represents -C(=O)-aryl or -C(=O)-heteroaryl;R3 represents hydrogen, methyl (which may be in either the alpha or beta configuration) or methylene;R4 and R5 are the same or different and each represents hydrogen or halogen; and<CUSTOM-CHARACTER FILE="US06878698-20050412-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> represents a single or a double bond;and salts and solvates thereof together with a long-acting beta2-adrenoreceptor agonist which formulation has a therapeutically useful effect in the treatment of COPD over a period of 24 hours or more.