ГЕН STREPTOMYCES AVERMITILIS И ЕГО ПРИМЕНЕНИЕ ДЛЯ ИЗМЕНЕНИЯ СООТНОШЕНИЯ АВЕРМЕКТИНОВ B2:B1

摘要

The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the ave C gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.