PYRAZOLOPYRROLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

摘要

The present invention provides compounds of formula (I): or a pharmaceutically
acceptable derivative thereof, wherein A, B, Q, R1, and R2 are as described in
the specification. These compounds are inhibitors of protein kinase,
particularly inhibitors of AKT or PDK1 kinase, mammalian protein kinases
involved in proliferative and neurodegenerative disorders. The invention also
provides pharmaceutical compositions comprising the compounds of the
invention, processes for preparing the compounds, and methods of utilizing
those compositions in the treatment of various disorders.