发明名称 |
Prokineticin polypeptides, related compositions and methods |
摘要 |
The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.
|
申请公布号 |
US2005074758(A1) |
申请公布日期 |
2005.04.07 |
申请号 |
US20030415724 |
申请日期 |
2003.08.19 |
申请人 |
ZHOU QUN-YONG;EHLERT FREDERICK J |
发明人 |
ZHOU QUN-YONG;EHLERT FREDERICK J |
分类号 |
G01N33/50;A61K38/00;A61K39/00;A61P1/00;A61P29/00;A61P31/00;A61P35/00;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12Q1/02;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C12Q1/68;C07H21/04 |
主分类号 |
G01N33/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|