INACTIVATED HOST CELL DELIVERY OF POLYNUCLEOTIDES ENCODING IMMUNOGENS

摘要

Applicants have found that an immune response can be elicited via the administration of an inactivated host cell comprising a polynucleotide encoding an immunogen. Despite the inactivation of the host cell prior to administration to the mammal, the encoded immunogen is expressed in vivo, apparently by the mammalian cellular machinery. The resulting immune response is specific to the encoded immunogen.