PIPERIDINE DERIVATIVE HAVING NMDA RECEPTOR ANTAGONISTIC ACTIVITY

摘要

A piperidine derivative represented by the formula (I) was found to specifically bond to an NR1/NR2B receptor and be usable as an analgesic (therapeutic agent for pains). [Chemical formula 1] (In the formula, X is OH or lower alkylsulfonyloxy; Ar is optionally substituted aryl or optionally substituted heteroaryl; n is an integer of 1 to 4; m is an integer of 0 to 1; and R<1> is hydrogen and R<2> is OH or R<1> and R<2> in combination may form a single bond, provided that the following cases 1) and 2) are excluded: 1) n is 2, m is 0, R<1> and R<2> in combination form a single bond, and Ar is optionally substituted phenyl and 2) n is 3, m is 0, R<1> and R<2> in combination form a single bond, and Ar is phenyl.)