HUMAN MONOCLONAL ANTIBODIES TO CTLA-4

摘要

PROBLEM TO BE SOLVED: To provide fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4).

SOLUTION: Provided is a fully human monoclonal antibody against CTLA-4. Nucleotide sequences encoding and amino acid sequences including heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.

COPYRIGHT: (C)2005,JPO&NCIPI