发明名称 |
Use of Pelargonium plant parts or extracts for treating chronic and/or post-viral fatigue syndrome and/or disease-associated behavioral changes, e.g. depression and tiredness |
摘要 |
<p>The use of extracts or parts of Pelargonium species plants is claimed in the prophylaxis and/or treatment of disease-associated behavioral changes and/or chronic and/or post-viral fatigue syndrome, is new. ACTIVITY : Immunomodulator; Antidepressant; CNS-Gen.; Eating-Disorders-Gen.; Muscular-Gen.; Hypnotic; Tranquilizer; Analgesic. MECHANISM OF ACTION : None given. A dry extract (I) of Pelargonium sidoides roots (obtained in 11% yield by macerating the roots twice with a 7-fold amount of 11 wt.% ethanol at 55 [deg]C) was administered orally to mice, followed an hour later by intraperitoneal injection of lipopolysaccharide (LPS) at 400 Microg/kg. The mice were subjected to exploration behavioral tests for 3 minutes in a light-dark box. The average time spent in the light area was 83 seconds for vehicle-only controls, 134 seconds after treatment with LPS only, 119 seconds after treatment with LPS plus (I) at 100 mg/kg, 104 seconds after treatment with LPS plus (I) at 200 mg/kg and 97 seconds after treatment with LPS plus (I) at 100 mg/kg. (I) thus caused dose-dependent inhibition of LPS-induced behavioral changes.</p> |
申请公布号 |
DE10350338(B3) |
申请公布日期 |
2005.04.07 |
申请号 |
DE2003150338 |
申请日期 |
2003.10.29 |
申请人 |
ISO ARZNEIMITTEL GMBH & CO KG |
发明人 |
CHATTERJEE, SHYAM SUNDER;KOCH, EGON;NOELDNER, MICHAEL |
分类号 |
A61K36/185;A61P25/24;A61P43/00;(IPC1-7):A61K35/78 |
主分类号 |
A61K36/185 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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