| 发明名称 |
MEMBRANE PREPARATION FROM PICHIA PASTORIS TO ASSAY gamma-SECRETASE ACTIVITY |
| 摘要 |
<p>Screening methods for identifying compounds that inhibit gamma-secretase activity are provided. The screening methods involve the generation of a transgenic P. pastoris expressing PS1, APH-1, PEN-2, and nicastrin. Test compounds can be screened for the ability to modulate gamma-secretase activity in vivo or in vitro.</p> |
| 申请公布号 |
WO2005031363(A1) |
申请公布日期 |
2005.04.07 |
| 申请号 |
WO2004US31230 |
申请日期 |
2004.09.23 |
| 申请人 |
UNIVERSITY OF CHICAGO;SISODIA, SANGRAM, S.;YU, CHUNJIANG |
发明人 |
SISODIA, SANGRAM, S.;YU, CHUNJIANG |
| 分类号 |
C12Q1/02;G01N33/68;(IPC1-7):G01N33/68;C12N15/81 |
主分类号 |
C12Q1/02 |
| 代理机构 |
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代理人 |
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| 主权项 |
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