发明名称 |
Transgenic animals for analysing cyp3a4 cytochrome p450 gene regulation |
摘要 |
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steriod, on the regulation of expression of the CYP3A4 gene in a human.
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申请公布号 |
US2005076397(A1) |
申请公布日期 |
2005.04.07 |
申请号 |
US20030415607 |
申请日期 |
2003.11.20 |
申请人 |
LIDDLE CHRISTOPHER;GOODWIN BRYAN JAMES;ROBERTSON GRAHAM |
发明人 |
LIDDLE CHRISTOPHER;GOODWIN BRYAN JAMES;ROBERTSON GRAHAM |
分类号 |
A61K49/00;C12N9/02;C12N15/85;(IPC1-7):A01K67/027 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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