A TRANSGENIC ANIMAL MODEL FOR CANCER AND STEM CELLS

摘要

The present invention provides methods and compositions for identifying stem cells and/or cancer cells in non-human animals. The compositions include vectors comprising elements suitable for integration into a licensing factor gene such that a cell harboring the chromosome into which the vector elements have integrated expresses a reporter transgene. The methods comprise the detection of stem and/or cancer cells by detecting the expression of the reporter transgene.