摘要 |
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity. |
申请人 |
AVI BIOPHARMA, INC.;IVERSEN, PATRICK, L.;MOULTON, HONG, M.;NELSON, MICHELLE, H.;KROEKER, ANDREW, D.;STEIN, DAVID, A. |
发明人 |
IVERSEN, PATRICK, L.;MOULTON, HONG, M.;NELSON, MICHELLE, H.;KROEKER, ANDREW, D.;STEIN, DAVID, A. |