EFFERVESCENT GRANULATED MATERIAL AND METHOD FOR ITS PREPARATION

摘要

The effervescent granulated material for a pharmaceutical preparation contains calcium carbonate and citric acid, where 5 to 20 parts by weight of the total acid provided for the reaction with the calcium carbonate are replaced by at least one of the following compounds: malic acid, gluconic acid and lactic acid as well as their (preferably acid) salts. Citric acid and calcium carbonate are granulated with an attendant partial reaction, and in each case at least a part of the compound partially replacing the citric acid is granulated in solid, powdered form together with the citric acid and the calcium carbonate and/or dissolved in granulation liquid or buffer solution.