| 摘要 |
1,175,468. Pharmaceutical compositions. E. MERCK, A.G. 20 Aug., 1968 [19 Oct., 1967], No. 39730/68. Heading A5B. Pharmaceutical compositions for the treatment of climacteric disorders comprise at least one physiologically compatible salt of oestrone sulphate and at least one physiologically compatible salt of the 3-sulphate of 1, 3, 5 (10)- oestratriene-3, 17#-diol, together with a solid and/or liquid pharmaceutical diluent or carrier. The salts may be alkali metal, alkaline earth metal, aluminium, iron, ammonium or substituted ammonium salts, preferably the sodium salts. The compositions may be administered parenterally as solutions, suspensions, or emulsions or enterally as tablets, dragees, syrups or juices. The composition may contain at least one additional active substance which may be selected from tranquillising substances, vitamins and steroids (e.g. oestrogens, androgens or gestragens such as chlormadinone acetate). Stabilizers, e.g. diethanolamine, N-methyl-glucosamine, sodium citrate, sorensen's buffer (a mixture of disodium hydrogen phosphate and potassium dihydrogen phosphate), and magnesium oxide may be present.
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