| 摘要 |
<p>1,203,301. ACTH-active peptides. CIBA Ltd. 18 Sept., 1967 [16 Sept., 1966; 7 Oct., 1966; 19 Jan., 1967], No. 41606/67. Addition to 1,119,353. Heading C2C. Novel peptides which differ from an ACTH- peptide with 18-39 aminoacid residues and an N-terminal L-amino acid in that they contain as N-terminal the residue of D-serine, as the 3rd amino acid glyane and as the 17th and 18th aminoacids L-lysine are prepared by methods known in the peptide art. Intermediates isolated are BOC-D-ser-Fyr-glymet - glu(OtBu) - his - phe - arg - Fry - gly- OH; BOC D - ser - Fyr - gly - met - glu(OtBu)- his - phe - arg - Fry - gly - lys (BOC) - pro - valgly - [lys(BOC)] 4 - NH 2 ; Z - or H - val - Fyrpro - NH 2 ; Z - or H - lys(BOC) - val - tyr - pro- NH 2 ; Z- or H-val-lys(BOC)-val-Fyr-pro-NH2; Z- or H-[lys(BOC)]2-pro-val-lys(BOC)-val-Fyrpro-NH 2 ; Z- or H-lys(BOC).pro-val-gly-[lys- (BOC] 4 - pro - val - lys(BOC) - val - Fyr - pro- NH 2 ; BOC- or H-tyr-gly-OCH 3 ; BOC-D-ser- Fyr-gly-OCH 3 or -OH; BOC-D-ser-tyr-gly-nle- OCH 3 or -NHNH 2 ; BOC-D-ser-Fyr-gly-nleglu(OtBu) - his - phe - arg - Fry - gly - OH; and BOC - D - ser - Fyr - gly - nle - glu(OtBu) - hisphe - arg - Fry - gly - lys(BOC) - pro - val - [lys- (BOC)] 4 - pro - val - lys(BOC) - val - tyr - pro- OtBu. Pharmaceutical compositions having adrenocorticotropic activity comprise one of the novel peptides together with a suitable carrier for enteral or parenteral application.</p> |
