发明名称 |
3-HYDROXY-4-OXO-1,2,3-TRIAZINES AND DERIVATIVES THEREOF FOR AMIDE AND ESTER BOND FORMATION |
摘要 |
The present invention relates to the use of a compound of formula I as a coupling reagent in forming amide or ester bonds from a reaction between a carboxylic acid and an amine or an alcohol, respectively. The compounds of formula I are especially useful as coupling reagents in the preparation of peptide bonds during peptide synthesis. In particular, the compounds of formula I are useful in promoting the formation of reactive reaction intermediates, inhibiting side reactions and in suppression of racemization. In addition, the present invention provides novel compounds of Formula I, and salts of N-oxides thereof.
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申请公布号 |
WO2005007634(A8) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2004IL00652 |
申请日期 |
2004.07.18 |
申请人 |
FRUTAROM LTD.;SHPERNAT, YAACOV;MIZHIRITSKII, MICHAEL |
发明人 |
SHPERNAT, YAACOV;MIZHIRITSKII, MICHAEL |
分类号 |
C07D253/04;C07D253/08;C07D471/04;C07D487/04;C07F9/6521;C07F9/6558;C07F9/6561;(IPC1-7):C07D253/04 |
主分类号 |
C07D253/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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