发明名称 |
METHOD OF TREATING TUMORS |
摘要 |
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody. |
申请公布号 |
WO2004010951(A8) |
申请公布日期 |
2005.03.31 |
申请号 |
WO2003US23845 |
申请日期 |
2003.07.30 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MERCK PATENT GMBH |
发明人 |
DENARDO, SALLY, J.;BURKE, PATRICIA, A.;DENARDO, GERALD, L.;GOODMAN, SIMON;MATZKU, SIEGFRIED DI |
分类号 |
A61K38/00;A61K38/12;A61K51/08;A61P7/00;A61P9/00;A61P19/00;A61P27/00;A61P31/00;A61P35/00;C07K16/30 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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