5-AMINOSALICYLIC ACID SOLID PREPARATION IMPROVED IN DISCOLORATION AND METHOD OF STORING THE SAME

摘要

The change to brown color of 5-aminosalicylic acid solid preparations is inhibited, and the properties as drug product at production of 5-aminosalicylic acid solid preparations are preserved for a prolonged period of time. There are provided solid preparations obtained by formulating of 5-aminosalicylic acid or its salt and a discoloration preventive agent into medical preparations, which solid preparations exhibit in CIELAB color space a color difference of 10.5 or less brought about by storage at 80°C for one week. The above discoloration preventive agent is characterized by containing at least one member selected from the group consisting of a thiol compound, a sulfide compound, an acid anhydride and hygroscopic compounds.